After reading this article we will learn about the Hardy-Weinberg equilibrium of gene. In a large random mating population, both gene and genotype frequencies remain constant from generation to generation, in absence of migration, mutation and selection. These properties of a population were first demonstrated by Hardy and Weinberg independently in 1908, and are generally known as Hardy-Weinberg law. If [...]
Let us make an in-depth study of the gene therapy strategies designed to interfere with the HIV-1 life-cycle. Basically Inhibition has been Envisaged at Three Major Levels: (i) Blocking HIV-1 infection: HIV-1 normalÂly infects T lymphocytes by binding of the viral gp120 envelope protein to the CD4 receptor on the cell membrane. Transfer of a gene encoding a soluble form [...]
The below mentioned article provides notes on overlapping gene. In 1940s, Beadle and Tatum proposed one-gene-one protein hypothesis which explains that one gene encodes for one protein. However, if one gene consists of 1,500 base pairs, a protein of 500 amino acids in length would be synthesized. In addition, if the same sequence read in two different ways, two different [...]