This article provides an overview on the principles of gene transfer. Classical gene therapies normally require efficient transfer of cloned genes into disease cells so that the introduced genes are expressed at suitably high levels. In principle, there are numerous different physicochemical and biological methods that can be used to transfer exogenous genes into human cells. The size of DNA [...]
Let us make an in-depth study of the gene therapy principles for neoplastic disorders and infectious diseases. Cancer Gene Therapies: Many different approaches can be used for cancer gene therapy (see Culver and Blaese, 1994 and Table 23.6) and, in marked contrast to the few gene therapy trials for inherited disorders, numerous cancer gene therapy trials are currently being conducted [...]
This article throws light upon the following three main types of gene action. The types are: 1. Additive Gene Action 2. Dominance Gene Action 3. Epistasis. Type # 1. Additive Gene Action: When the genes act in such a way that substitution of one allele for another produces same plus or minus effect regardless of other gene (s) and the [...]