The below mentioned article provides a close look on the gene therapy designed for inherited diseases. Different genetic disorders are amenable to varying degrees to treatment by gene therapy. Common non-Mendelian genetic diseases may involve a complex interplay between different genetic loci and/or environmental factors, and so possible gene therapy approaches may not be .straightforward. Single gene disorders, where individuals [...]
In this article we will discuss about the principles and applications of gene therapy based on targeted inhibition of gene expression in vivo. Principles and Applications of Therapy Based on Targeted Inhibition of Gene Expression In Vivo: One way of treating certain human disorders is to selectively inhibit the expression of a predetermined gene in vivo. In principle, this general [...]
This article throws light upon the following three main types of gene action. The types are: 1. Additive Gene Action 2. Dominance Gene Action 3. Epistasis. Type # 1. Additive Gene Action: When the genes act in such a way that substitution of one allele for another produces same plus or minus effect regardless of other gene (s) and the [...]