The below mentioned article provides a close look on the gene therapy designed for inherited diseases. Different genetic disorders are amenable to varying degrees to treatment by gene therapy. Common non-Mendelian genetic diseases may involve a complex interplay between different genetic loci and/or environmental factors, and so possible gene therapy approaches may not be .straightforward. Single gene disorders, where individuals [...]
In this article we will discuss about the principles and applications of gene therapy based on targeted inhibition of gene expression in vivo. Principles and Applications of Therapy Based on Targeted Inhibition of Gene Expression In Vivo: One way of treating certain human disorders is to selectively inhibit the expression of a predetermined gene in vivo. In principle, this general [...]
In this article we will discuss about the examples of pedigree pattern of autosomal and sex chromosomal genetic diseases. 1. Pedigree pattern of an autosomal dominant trait. Note the vertical pattern of inheritance. Solid squares and circles indicating the affected males and females while hollow squares and circles are unaffected males and females. 2. Pedigree patterns of an autosomal recessive [...]