In this article we will discuss about the evolution of exon structure. Average cellular gene is vertebrates contains about eight exons and detail analysis of human gene has yielded a classification scheme for exons according to their transcriptional or translational boundaries. According to this scheme there are 12 different categories which are: (i) 5' terminal un-translated exons. (ii) 3' terminal [...]
In this article we will discuss about the chromosome abnormalities in human cancer cell. Many human cancer cells have chromosome abnormalities and frequently specific abnormalities are associated with specific forms of cancer. Chromosome abnormalities in human cancer cells can involve both the number and, more frequently, the structure of the chromosome. Number of abnormalities are mostly due to non-disjunction and [...]
The below mentioned article provides a close look on the gene therapy designed for inherited diseases. Different genetic disorders are amenable to varying degrees to treatment by gene therapy. Common non-Mendelian genetic diseases may involve a complex interplay between different genetic loci and/or environmental factors, and so possible gene therapy approaches may not be .straightforward. Single gene disorders, where individuals [...]