In this article we will discuss about the co-linearity between genes and proteins. The most convincing demonstration of the relationship between genes and their product proteins came from two separate investigators, one by C. Yanofsky and his colleagues working on the tryptophan synthetase system in E. coli, the other from Sarabhai and his team who were studying bacteriophage. Yanofsky (1967) [...]
A mRNA may be associated with several ribosomes (polysomes) in a cell actively engaged in protein synthesis. The process takes place in 4 major steps namely activation of amino acids, chain initiation, elongation and termination. Each step is controlled by specific enzymes and cofactors. Step # 1. Activation of Amino Acids: The amino acids are activated by a class of [...]
The below mentioned article provides notes on central dogma. However, DNA itself does not directly order amino acid sequences. In 1958 Francis Crick suggested an RNA intermediate and proposed that there is a one-way sequential flow of information from DNA to RNA to protein. This relationship of information transfer between DNA and protein became the Central Dogma (meaning a set [...]