After reading this article you will learn about the concept and types of pharmacokinetic models. Concept of Pharmacokinetic Models: Drugs remain in dynamic state within the body and drug events often happen simultaneously. In order to describe a complex biologic system, assumptions are made concerning the movement of drugs. The mathematical models are used to describe the absorption, distribution and [...]
After reading this article you will learn about the dosage regimen of a drug. Many drugs like antibiotics, cardio tonics, anticonvulsants, hormones etc. are generally given in a multiple-dosage for prolonged therapeutic effect. The plasma concentrations of these drugs must be maintained within narrow limits to achieve maximal clinical effectiveness. A dosage regimen must be established for each drug to [...]
The plasma level time curve is plotted after measured drug concentration in plasma of an animal at different time intervals. The concentrations of drug in each plasma sample are plotted on an ordinary graph paper against the corresponding time at which the plasma samples were collected. As the drug reaches in systemic circulation, plasma drug concentration will rise to a [...]