Archive | Pharmacokinetics

Physiological Factors and Drug Absorption | Pharmacokinetics

This article throws light upon the eight main physiological factors that affect the rate of drug absorption. The factors are: 1. Passage of Drug Molecule Across Membranes 2. pKa 3. pH - pka Partion Concept 4. pH-Partition Hypothesis 5. Active Transport 6. Facilitated Diffusion 7. Pinocytosis (Vesicular Transport) 8. Pore or Convective Transport. Physiologic Factor # 1. Passage of Drug [...]

By |2017-03-04T09:34:56+00:00March 4, 2017|Pharmacokinetics|Comments Off on Physiological Factors and Drug Absorption | Pharmacokinetics

Metabolism of Drugs | Pharmacokinetics

After reading this article you will learn about: 1. Definition and Need of Metabolism 2. Types of Metabolism. Definition and Need of Metabolism: Metabolism is a process of alteration of drugs in the body so as to modify their activity and structure. If lipophylic drugs are not metabolized it will be reabsorbed by the kidney tubule and will circulate in [...]

By |2017-03-04T09:34:56+00:00March 4, 2017|Pharmacokinetics|Comments Off on Metabolism of Drugs | Pharmacokinetics

Dosage Regimen of a Drug | Pharmacokinetics

After reading this article you will learn about the dosage regimen of a drug. Many drugs like antibiotics, cardio tonics, anticonvulsants, hormones etc. are generally given in a multiple-dosage for prolonged therapeutic effect. The plasma concentrations of these drugs must be maintained within narrow limits to achieve maximal clinical effectiveness. A dosage regimen must be established for each drug to [...]

By |2017-03-04T09:34:56+00:00March 4, 2017|Pharmacokinetics|Comments Off on Dosage Regimen of a Drug | Pharmacokinetics
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