This article throws light upon the three main routes of drug administration. The routes are: 1. Topical or External Application 2. Oral or Enteral Route 3. Parenteral Route (Injection). Route # 1. Topical or External Application: The drugs administration by this route generally affects to the part to which they are applied. However, some drugs applied topically are absorbed from [...]
The plasma level time curve is plotted after measured drug concentration in plasma of an animal at different time intervals. The concentrations of drug in each plasma sample are plotted on an ordinary graph paper against the corresponding time at which the plasma samples were collected. As the drug reaches in systemic circulation, plasma drug concentration will rise to a [...]
This article throws light upon the three main types of pharmacokinetic variables of drugs. The variables are: 1. Plasma Half-Life (t1/2β) 2. Volumes of Distribution 3. Total Body Clearance (CIB). Type # 1. Plasma Half-Life (t1/2β): Half-life is defined as the time of declining the initial plasma drug concentration by half. It is also known as the half-time of elimination [...]