In this article we will discuss about the approaches made for codon assignments. 1. Codon Assignment with Unknown Sequences: Theoretically it was considered that genetic code should be triplet so that codons must be assigned for 20 amino acids. But it was not known which codon synthesizes which amino acid. Therefore, the first approach was made to find out the [...]
In this article we will discuss about the concept of wobble hypothesis. Crick (1966) proposed the 'wobble hypothesis' to explain the degeneracy of the genetic code. Except for tryptophan and methionine, more than one codons direct the synthesis of one amino acid. There are 61 codons that synthesise amino acids, therefore, there must be 61 tRNAs each having different anticodons. [...]
The dictionary of coded language of genetic information is called cryptogram. The simplest and smallest possible code is a single code or singlet code which specifies that one amino acid is synthesized by one nucleotide. Singlet code is not possible for coding 20 different amino acids. Then how many letters would be used as a code for a single amino [...]