The following points highlight the nine important types of metal-nucleic acid interactions. Some of the types are:- 1. Coordination 2. Intercalation and Hydrogen Bonding 3. Fundamental Reactions with Nucleic Acids 4. Structural Role of Metal/Nucleic Acid Interactions 5. Regulatory Role of Metal/Nucleic Acid Interactions 6. Pharmaceutical Role of Metal/Nucleic Acid Interactions and Others. Type # 1. Coordination: Most prevalent among [...]
Let us make an in-depth study of the gene therapy principles for neoplastic disorders and infectious diseases. Cancer Gene Therapies: Many different approaches can be used for cancer gene therapy (see Culver and Blaese, 1994 and Table 23.6) and, in marked contrast to the few gene therapy trials for inherited disorders, numerous cancer gene therapy trials are currently being conducted [...]
In this article we will discuss about the development of tumour suppressor genes. Inactivation of tumour suppressor genes also contributes to development of tumours. Normally, tumour suppressor genes act to inhibit cell proliferation and tumour development. When these genes are inactivated or lost they lead to abnormal proliferation of tumour cells. The first tumour suppressor gene was identified through studies [...]