This article provides an overview on the principles of gene transfer. Classical gene therapies normally require efficient transfer of cloned genes into disease cells so that the introduced genes are expressed at suitably high levels. In principle, there are numerous different physicochemical and biological methods that can be used to transfer exogenous genes into human cells. The size of DNA [...]
The following points highlight the nine important types of metal-nucleic acid interactions. Some of the types are:- 1. Coordination 2. Intercalation and Hydrogen Bonding 3. Fundamental Reactions with Nucleic Acids 4. Structural Role of Metal/Nucleic Acid Interactions 5. Regulatory Role of Metal/Nucleic Acid Interactions 6. Pharmaceutical Role of Metal/Nucleic Acid Interactions and Others. Type # 1. Coordination: Most prevalent among [...]
Let us make an in-depth study of the gene therapy principles for neoplastic disorders and infectious diseases. Cancer Gene Therapies: Many different approaches can be used for cancer gene therapy (see Culver and Blaese, 1994 and Table 23.6) and, in marked contrast to the few gene therapy trials for inherited disorders, numerous cancer gene therapy trials are currently being conducted [...]