In this article we will discuss about the discovery and special features of genetic code. Once the role of DNA as a hereditary material was established, it was clear that DNA contained the information for the formation of protein molecules or polypeptides. The sequence of purines and pyrimidines bases along the DNA molecule determines the sequence of amino acids in [...]
In this article we will discuss about the basics of mutation screening by Denaturing High-Performance Liquid Chromatography (DHPLC). Introduction to Basics of Mutation by DHPLC: Studies of sequence variation are an integral part of genome research, because of differences in the genomic sequences between individuals. Variations in mammalian genomic sequences occur at an estimated frequency of at least one base [...]
In this article we will discuss about the novel DHPLC based strategy for identification and characterisation of (BI)-Clonal T-Cell receptor targets for the detection of minimal residual disease in childhood acute lymphoblastic leukemia. Introduction: Clonal antigen receptor rearrangements are widely used as patient-specific markers for detection of minimal residual disease (MRD) in acute lymphoblastic Leukemia (ALL). Since ALL blasts are [...]