The below mentioned article provides notes on colchicine. In 1937 O.G. Eigsti first succeeded in inducing tetraploidy in cells of onion root tips by the chemical colchicine. This is an alkaloid obtained from the seed and corm of liliaceous plant Colchicum autumnale. In high concentrations the drug is highly toxic to cells. If used in concentrations as low as 0.01% [...]
In this article we will discuss about the co-linearity between genes and proteins. The most convincing demonstration of the relationship between genes and their product proteins came from two separate investigators, one by C. Yanofsky and his colleagues working on the tryptophan synthetase system in E. coli, the other from Sarabhai and his team who were studying bacteriophage. Yanofsky (1967) [...]
The below mentioned article provides notes on central dogma. However, DNA itself does not directly order amino acid sequences. In 1958 Francis Crick suggested an RNA intermediate and proposed that there is a one-way sequential flow of information from DNA to RNA to protein. This relationship of information transfer between DNA and protein became the Central Dogma (meaning a set [...]