In this article we will discuss about the mutation analysis of LDLR mutations in patients with familial hypercholesterolaemia. Introduction to Mutation Detection in the LDLR Gene: In some families, the risk of early coronary heart disease is considerably raised by the inheritance of a specific mutation, in one of two genes (apolipoprotein B, ApoB [OMIM #107730], or low-density lipoprotein receptor, [...]
In this article we will discuss about the isolation and sequencing of heteroduplex fragments from DHPLC analysis of somatic, low-frequency mutations. Introduction to Isolation and Sequencing of Mutations by DHPLC: Identification of somatic mutations in samples from solid tumors represent some additional challenges compared to the identification of heterozygous germline mutations. Biopsies from solid tumors often contain various amounts of [...]
Read this article in Hindi to learn about the Mendelian theories and its explanations. मेंडल के वंशागति के नियमों में पृथक्ककरण का नियम (law of segregation) की जानकारी के अनुसार किसी जीन के एलील गैमीट बनते समय एक-दूसरे से पृथक हो जाते हैं अत: जितने प्रकार के गैमीट बनेंगे (विशुद्ध एवं संकर) F1 या F2 में संतति उतने ही प्रकार [...]