A proteinaceous factor termed as maturation promoting factor (MPF), subsequently renamed as mitosis promoting factor, is identified and purified (Masui, Markert, Mailer). MPF is a heterodimer complex between kinase - a catalytic sub- unit and cyclin - a regulatory subunit (Fig. 5.27A). Kinase enzyme brings about phosphorylation of specific target proteins at different stages of the cell cycle which is [...]
The below mentioned article provides a short note on the Coupling and Repulsion Hypothesis of Gene. Bateson and Punnett in 1906, described a cross in sweat pea, where failure of gene pairs to assort independently was exhibited. Plants of a sweat pea variety having blue flower (BB) and long pollen (LL) were crossed with those of another variety having red [...]
The below mentioned article provides a short note on the Homeotic Genes. Homeotic genes constitute an intricate regulatory network, in which one gene may activate or repress other genes Homeotic genes are involved in regulation of development through a predetermined pathway in which specific genes are turned on and off at particular times. Homeotic genes act in a transcriptional cascade, [...]