The following points highlight the three main types of inheritance with its characteristics. The types are: 1. Autosomal Dominant Inheritance 2. Autosomal Recessive Inheritance 3. Polygenic Disorders and Multifactorial Inheritance. Type # 1. Autosomal Dominant Inheritance: Farabee in 1905 gave the first description of a pedigree showing brachydactyly (short fingers and toes), an autosomal dominant trait. Some more examples are [...]
In this article we will discuss about the study of a complete chromosomes. For karyotype analysis, a sample of peripheral blood is drawn from an individual, the leukocytes separated and cultured for about 3 days. To stimulate growth and cell division phyto-haemaglutinin (PHA) is added. The dividing lymphocytes are arrested at metaphase stage by exposing them to colchicine. The cells [...]
The following points highlight the four main types of chromosomal anomalies. The types are: 1. Autosomal Anomalies 2. Sex Chromosome Anomalies 3. Chromosomes and Spontaneous Abortions 4. Chromosomes in Disorders with DNA Repair Defects. Type # 1. Autosomal Anomalies: The first known case of a chromosomal anomaly associated with a clinical disorder was described by Lejeune. Gautier and Turpin in [...]