The MHC has been divided into three regions on the basis of structure, function and alloreactivity of the gene products, which-are: 1. Class - I at the telomeric ends 2. Class - II at the centromeric ends 3. Class - III, which is located between class - I and II regions. The classic class I and II genes code for [...]
This article provides an overview on the principles of gene transfer. Classical gene therapies normally require efficient transfer of cloned genes into disease cells so that the introduced genes are expressed at suitably high levels. In principle, there are numerous different physicochemical and biological methods that can be used to transfer exogenous genes into human cells. The size of DNA [...]
The following points highlight the nine important types of metal-nucleic acid interactions. Some of the types are:- 1. Coordination 2. Intercalation and Hydrogen Bonding 3. Fundamental Reactions with Nucleic Acids 4. Structural Role of Metal/Nucleic Acid Interactions 5. Regulatory Role of Metal/Nucleic Acid Interactions 6. Pharmaceutical Role of Metal/Nucleic Acid Interactions and Others. Type # 1. Coordination: Most prevalent among [...]