In this article we will discuss about the rules regarding the recording a pedigree. A detailed health history of the family is the basic prerequisite for any form of genetic counselling and it is essential to have detailed information about the patient's (supposed to have any genetic abnormality or disease) relatives. A detailed pedigree gives us the necessary basic information [...]
In this article we will discuss about the control of the synthesis of haemoglobin. 1. The Control of the Rate of Synthesis of the Peptide Chains. i. Rate of synthesis of Normal peptide chains: Approximately 95% of the red cell protein is haemoglobin. The peptide chains of haemoglobins are thus synthesized at a rate much higher than that of any [...]
In this article we will discuss about the genetics of thalassemia. There are two main types of thalassemia: α-thalassemia — resulting from a reduced rate of α-chain; β-thalassemia — resulting from a defective production of β-chains. More recently, family studies have revealed a heterogeneity of both α and β- thalassemia which is discussed in the Table 15.1. The β-thalassemias are [...]