In this article we will discuss about the examples of genetic linkage in humans. Also learn its clinical applications. 1. Nail-Patella Syndrome and ABO Blood Groups: This genetic linkage has been demonstrated by Reneisck and Lawler (1955). The nail- patella syndrome or hereditary onychosteodysplasia is characterised by a constellation of abnormalities. The nail dystrophy is variable, ranging from a triangular [...]
In this article we will discuss about some common misconceptions and misinterpretations about genetic disorders. It is important to recognize that there are many potential misconceptions concerning genetic disorders and risks that need to be identified and rectified to ensure that families understand the information they are given and can use it appropriately. Some common misconceptions and misinterpretations are as [...]
In this article we will discuss about the examples of pedigree pattern of autosomal and sex chromosomal genetic diseases. 1. Pedigree pattern of an autosomal dominant trait. Note the vertical pattern of inheritance. Solid squares and circles indicating the affected males and females while hollow squares and circles are unaffected males and females. 2. Pedigree patterns of an autosomal recessive [...]