In this article we will discuss about the genetics of thalassemia. There are two main types of thalassemia: α-thalassemia — resulting from a reduced rate of α-chain; β-thalassemia — resulting from a defective production of β-chains. More recently, family studies have revealed a heterogeneity of both α and β- thalassemia which is discussed in the Table 15.1. The β-thalassemias are [...]
In this article we will discuss about the diversity of retroviral oncogenes. Studies of other retroviruses of several different animal species (most notably the mouse, rat, chicken, and certain species of monkeys) soon led to the identification of other retroviral oncogenes. Over 20 different retroviral oncogene (Table 16.2) have been described to date, and more undoubtedly remain to be discovered. [...]
In this article we will discuss about the examples of genetic linkage in humans. Also learn its clinical applications. 1. Nail-Patella Syndrome and ABO Blood Groups: This genetic linkage has been demonstrated by Reneisck and Lawler (1955). The nail- patella syndrome or hereditary onychosteodysplasia is characterised by a constellation of abnormalities. The nail dystrophy is variable, ranging from a triangular [...]