In this article we will discuss about the structure of chromatin in the light of nucleosome. Preamble: A supercoil model for chromatin structure was originally described by Pardon and Wilkins in 1972. Later studies of Boldwin (1975), Kornberg (1974) and others have shown that such a sub-unit structure of chromatin is not only present in mammalian cells but also found [...]
In this article we will discuss about the genetics of thalassemia. There are two main types of thalassemia: α-thalassemia — resulting from a reduced rate of α-chain; β-thalassemia — resulting from a defective production of β-chains. More recently, family studies have revealed a heterogeneity of both α and β- thalassemia which is discussed in the Table 15.1. The β-thalassemias are [...]
In this article we will discuss about the diversity of retroviral oncogenes. Studies of other retroviruses of several different animal species (most notably the mouse, rat, chicken, and certain species of monkeys) soon led to the identification of other retroviral oncogenes. Over 20 different retroviral oncogene (Table 16.2) have been described to date, and more undoubtedly remain to be discovered. [...]