In this article we will discuss about the structure of chromatin in the light of nucleosome. Preamble: A supercoil model for chromatin structure was originally described by Pardon and Wilkins in 1972. Later studies of Boldwin (1975), Kornberg (1974) and others have shown that such a sub-unit structure of chromatin is not only present in mammalian cells but also found [...]
In this article we will discuss about the examples of genetic linkage in humans. Also learn its clinical applications. 1. Nail-Patella Syndrome and ABO Blood Groups: This genetic linkage has been demonstrated by Reneisck and Lawler (1955). The nail- patella syndrome or hereditary onychosteodysplasia is characterised by a constellation of abnormalities. The nail dystrophy is variable, ranging from a triangular [...]
In this article we will discuss about:- 1. Degree of Resemblance between Parent and Offspring 2. Result of Children of First Cousins Marriage 3. Result of Children of Parents who are Recessives 4. Random Expectations of Consanguinity and Others. Social authorities have prohibited consanguineous marriages (between close relatives who have the blood relations) since ancient times with some exceptions. Marriages [...]