The below mentioned article provides a close look on the gene therapy designed for inherited diseases. Different genetic disorders are amenable to varying degrees to treatment by gene therapy. Common non-Mendelian genetic diseases may involve a complex interplay between different genetic loci and/or environmental factors, and so possible gene therapy approaches may not be .straightforward. Single gene disorders, where individuals [...]
This article provides an overview on the principles of gene transfer. Classical gene therapies normally require efficient transfer of cloned genes into disease cells so that the introduced genes are expressed at suitably high levels. In principle, there are numerous different physicochemical and biological methods that can be used to transfer exogenous genes into human cells. The size of DNA [...]
In this article we will discuss about the principles and applications of gene therapy based on targeted inhibition of gene expression in vivo. Principles and Applications of Therapy Based on Targeted Inhibition of Gene Expression In Vivo: One way of treating certain human disorders is to selectively inhibit the expression of a predetermined gene in vivo. In principle, this general [...]