The Watson-Crick model of DNA has been the basis for further work on DNA replication, mutation and recombination. Much evidence exists to establish the validity of this model. Nevertheless, the model has been scrutinized by other workers, and from time to time other models have been suggested by Wu (1970), Arnott (1968), Wang (1979) and a few others. Wang's model [...]
In this article we will discuss about the repeated sequence of chromosomal DNA. Eukaryotic genomes contain large amount of repetitive sequences, sometimes present in hundreds or thousands of copies per genome. The understanding of repetitive sequences is based on studies conducted on denaturation (separation of DNA double helix into its two component strands) and renaturation (re-association of the single strands [...]
Introduction to Recombinant DNA Technology: Recombinant DNA technology has revolutionised life sciences, opening new vistas for research in molecular biology. It allows genetic manipulation using techniques for synthesizing, amplifying and purifying individual genes from any type of cell. Genomics has emerged as an extension of recombinant DNA technology for high resolution mapping and characterization of whole genomes and gene products [...]