Archive | Cytotoxicity

This article throws light upon the five assays developed for measuring the cell viability and cytotoxicity. The five assays are: (i) Cytotoxicity and Viability Assays (ii) Survival Assays (iii) Metabolic Assays (iv) Transformation Assays and (v) Inflammation Assays. As the cells are removed from the living (in vivo) environment and subjected to experimental manipulations in the culture systems (in vitro), [...]

This article throws light upon the limitations of in vitro cytotoxicity studies which are briefly described below. Toxicity of a given compound is a complex process as it occurs in vivo. This may result in direct damage to cells, alterations in physiological and biochemical functions, inflammatory changes and other systemic effects, not only at the site of application but also [...]