After reading this article you will learn about the concept and types of pharmacokinetic models. Concept of Pharmacokinetic Models: Drugs remain in dynamic state within the body and drug events often happen simultaneously. In order to describe a complex biologic system, assumptions are made concerning the movement of drugs. The mathematical models are used to describe the absorption, distribution and [...]
The plasma level time curve is plotted after measured drug concentration in plasma of an animal at different time intervals. The concentrations of drug in each plasma sample are plotted on an ordinary graph paper against the corresponding time at which the plasma samples were collected. As the drug reaches in systemic circulation, plasma drug concentration will rise to a [...]
After reading this article you will learn about the role and functions of second messengers. Many hormones, neurotransmitters, autacoids and drugs act on specific membrane receptors, the immediate consequence of which is activation of a cytoplasmic component of the receptor, which may be an enzyme such as adenylate cyclase, guanylate cyclase or activation of a transport systems or opening of [...]