In this article we will discuss about the secondary structure of Deoxyribonucleic Acids (DNA) and Ribonucleic Acids (RNA). Secondary Structure of Deoxyribonucleic Acids: Some observations made on deoxyribonucleic acids in solution suggested that DNA molecules — as they could be extracted from cells — had structural characteristics different from those expected in molecules having only the primary structure we just [...]
In this article we will discuss about the formation of purine and pyrimidine deoxyribonucleosies. Formation of Purine Deoxyribonucleosides-5'- Triphosphates: The deoxyribonucleotides are simply formed by reduction of the corresponding ribonucleotides. Thus reduction of carbon 2' of ribose, takes place in E.coli and animal tissues at the ribonucleosides-5'-diphosphates stage, at the cost of a protein of low molecular weight, thioredoxin, comprising [...]
The biosynthesis of the DNA must consist in a replication or duplication. The study of the DNA structure as proposed by Crick and Watson (see fig. 6-15) gives an idea of the mechanism of this replication. Each nucleotide of the template DNA chain need only be recognized by a complementary nucleotide before the latter is incorporated at the end of [...]