In this article we will discuss about the replication of eukaryotic chromosome. Taylor in 1958 used radioactive thymidine (3H-thymidine) to label Viciafaba root tip chromosomes. He showed that the chromosomes replicated in a semiconservative manner, and proposed that each chromatid was made up of a single DNA molecule. Thus each sister chromatid is composed of one of the two progeny [...]
The following points highlight the four main stages involved in synthesis of RNA. The stages are: 1. Binding of RNA Polymerase to DNA 2. Initiation of Transcription 3. Elongation of RNA chain 4. Termination of Transcription. Stage # 1. Binding of RNA polymerase to DNA: RNA polymerase binds to the "promoter site" on the DNA molecule. The promoter site is [...]
The below mentioned article provides a short note on DNA repair synthesis. Several types of damages, such as breakage in DNA strand, alteration of base pairs, cross linking of DNA with DNA or cross linking of DNA with proteins and pyrimidine dimer formation etc., may occur in chromosomes. These damages may be caused by mutagens produced within the cell itself [...]