Factors Affecting Local Anaesthetic Action | Drugs
This article throws light upon the three main factors affecting local anaesthetic action. The factors are: 1. Type of Nerve Fibre 2. pH and pKa 3. Potentiators. Factor # 1. Type of Nerve Fibre: Small (thinner) nerve fibres such as thinner sensory and postganglionic sympathetic fibres (C-type) and preganglionic sympathetic fibres (B-type) are most sensitive to conduction blockade by local [...]