Isolation and Sequencing of Mutations by DHPLC | Genetics | Biology
In this article we will discuss about the isolation and sequencing of heteroduplex fragments from DHPLC analysis of somatic, low-frequency mutations. Introduction to Isolation and Sequencing of Mutations by DHPLC: Identification of somatic mutations in samples from solid tumors represent some additional challenges compared to the identification of heterozygous germline mutations. Biopsies from solid tumors often contain various amounts of [...]