In this article we will discuss about the gene rearrangements in light and heavy chain DNAs. Rearranged k and λ genes of light chain contain gene segments in the order from 5' to 3' end- a short leader (L) gene segment, an intron (noncoding sequence), a joined VJ-gene segment, a second intron, and a C-gene segment (Fig. 22.18). The rearranged [...]
The following points highlight the nine important antigen-antibody reactions. They are: 1. Precipitation Reactions 2. Immunodiffusion Test 3. Counter Current Immunoelectroptioresis Test 4. Agglutination Reactions 5. Complement Fixation Reactions 6. Neutralization Reactions 7. Radioimmunoassay 8. Enzyme-Linked Immunosorbent Assay 9. Fluorescent Antibody Technique. 1. Precipitation Reactions: The reaction of soluble antigens with IgG or IgM antibodies to form a large interlocking [...]
In this article we will discuss about:- 1. Definition of MHC Molecules 2. Classes of MHC Molecules 3. Structure 4. Function 5. Gene Regulation. Definition of MHC Molecule: The term histocompatible refers to the individuals who the same tissues i.e. identical twins. This term is used to determine how identical two unrelated individuals are. In case of two histocompatible individuals, [...]