In this article we will discuss about the genetics of thalassemia. There are two main types of thalassemia: α-thalassemia — resulting from a reduced rate of α-chain; β-thalassemia — resulting from a defective production of β-chains. More recently, family studies have revealed a heterogeneity of both α and β- thalassemia which is discussed in the Table 15.1. The β-thalassemias are [...]
In this article we will discuss about:- 1. Definition of Down's Syndrome 2. Physical and Physiological Features of Down's Syndrome 3. Chromosomal Findings 4. Incidence 5. Causes. Definition of Down's Syndrome: The first autosomal abnormality described in man by John Langdon Down (1966) was known as Down's syndrome, more commonly used as mongolism. In this case, there is simple trisomy [...]
In this article we will discuss about the diversity of retroviral oncogenes. Studies of other retroviruses of several different animal species (most notably the mouse, rat, chicken, and certain species of monkeys) soon led to the identification of other retroviral oncogenes. Over 20 different retroviral oncogene (Table 16.2) have been described to date, and more undoubtedly remain to be discovered. [...]