In this article we will discuss about the history and induction of mutations. History of Mutation: The sudden heritable changes in genes, other than those due to Mendelian segregation and recombination constitute mutations. The idea of mutation first originated from observations of a Dutch botanist Hugo de Vries (in the 1880's) on variations in plants of Oenothera lamarckiana (evening primrose) [...]
In this article we will discuss about the development of tumour suppressor genes. Inactivation of tumour suppressor genes also contributes to development of tumours. Normally, tumour suppressor genes act to inhibit cell proliferation and tumour development. When these genes are inactivated or lost they lead to abnormal proliferation of tumour cells. The first tumour suppressor gene was identified through studies [...]
In this article we will discuss about the top two types of inherited diseases that are found in families. The diseases are: 1. Diabetes Mellitus 2. Muscular Dystrophies. Disease # 1. Diabetes Mellitus: This is a complex, heterogeneous condition which is frequently seen to recur in certain families. It is due to partial or complete lack of insulin which leads [...]