In this article we will discuss about the principles and applications of gene therapy based on targeted inhibition of gene expression in vivo. Principles and Applications of Therapy Based on Targeted Inhibition of Gene Expression In Vivo: One way of treating certain human disorders is to selectively inhibit the expression of a predetermined gene in vivo. In principle, this general [...]
Let us make an in-depth study of the gene therapy principles for neoplastic disorders and infectious diseases. Cancer Gene Therapies: Many different approaches can be used for cancer gene therapy (see Culver and Blaese, 1994 and Table 23.6) and, in marked contrast to the few gene therapy trials for inherited disorders, numerous cancer gene therapy trials are currently being conducted [...]
Let us make an in-depth study of the gene therapy strategies designed to interfere with the HIV-1 life-cycle. Basically Inhibition has been Envisaged at Three Major Levels: (i) Blocking HIV-1 infection: HIV-1 normally infects T lymphocytes by binding of the viral gp120 envelope protein to the CD4 receptor on the cell membrane. Transfer of a gene encoding a soluble form [...]