The below mentioned article provides a close look on the gene therapy designed for inherited diseases. Different genetic disorders are amenable to varying degrees to treatment by gene therapy. Common non-Mendelian genetic diseases may involve a complex interplay between different genetic loci and/or environmental factors, and so possible gene therapy approaches may not be .straightforward. Single gene disorders, where individuals [...]
In this article we will discuss about the principles and applications of gene therapy based on targeted inhibition of gene expression in vivo. Principles and Applications of Therapy Based on Targeted Inhibition of Gene Expression In Vivo: One way of treating certain human disorders is to selectively inhibit the expression of a predetermined gene in vivo. In principle, this general [...]
Let us make an in-depth study of the gene therapy strategies designed to interfere with the HIV-1 life-cycle. Basically Inhibition has been Envisaged at Three Major Levels: (i) Blocking HIV-1 infection: HIV-1 normally infects T lymphocytes by binding of the viral gp120 envelope protein to the CD4 receptor on the cell membrane. Transfer of a gene encoding a soluble form [...]