This article throws light upon the three main factors affecting local anaesthetic action. The factors are: 1. Type of Nerve Fibre 2. pH and pKa 3. Potentiators. Factor # 1. Type of Nerve Fibre: Small (thinner) nerve fibres such as thinner sensory and postganglionic sympathetic fibres (C-type) and preganglionic sympathetic fibres (B-type) are most sensitive to conduction blockade by local [...]
An Ideal Local Anaesthetic: An ideal local anaesthetic should qualify four principal qualities: it should be selective and effective for action and safe and stable for use. Selective: It should selectively block the function of sensory nerves (reversible paralysis) to produce local analgesia. Effective: It should be effective whether applied topically or upon injection. Onset of action should be rapid. [...]
Here is a list of twenty-four CNS stimulants. i. Analeptics: Analeptics are drugs which stimulate the C.N.S., particularly the respiratory and other vital centres in the medulla and are used to stimulate and revive the patients with depressed respiratory and cardiovascular centres due to overdose of CNS depressants and produce increased respiratory exchange. These are useful in barbiturates poisoning, drowning, [...]