After reading this article you will learn about the dosage regimen of a drug. Many drugs like antibiotics, cardio tonics, anticonvulsants, hormones etc. are generally given in a multiple-dosage for prolonged therapeutic effect. The plasma concentrations of these drugs must be maintained within narrow limits to achieve maximal clinical effectiveness. A dosage regimen must be established for each drug to [...]
After reading this article you will learn about:- 1. Factors Affecting Blood Concentration of a Drug 2. Absorption of Drug 3. Distribution 4. Dosage Forms 5. Nome nclature 6. Bioavailability 7. Apparent Volume of Distribution (VP) 8. Excretion. Factors Affecting Blood Concentration of a Drug: The following factors can affect the blood concentrations of a drug: (i) The route of [...]
This article throws light upon the eight main physiological factors that affect the rate of drug absorption. The factors are: 1. Passage of Drug Molecule Across Membranes 2. pKa 3. pH - pka Partion Concept 4. pH-Partition Hypothesis 5. Active Transport 6. Facilitated Diffusion 7. Pinocytosis (Vesicular Transport) 8. Pore or Convective Transport. Physiologic Factor # 1. Passage of Drug [...]