Tag Archives | Chemotherapeutic Agents

Chloramphenicol: Structure and Mechanism of Action | Antibiotics

In this article we will discuss about:- 1. Structure of Chloramphenicol 2. Antibiotic Spectrum of Chloramphenicol 3. Mechanism of Action. Structure of Chloramphenicol: Chemically, chloramphenicol is a simple structure (Fig. 45.12) made up of nitrobenzene ring bonded with non-ionic chlorine. It consists of two unusual components—one nitro (-NO2) group and a dichloroacetyl (-COCHCl2) group. The molecule possesses two asymmetric carbon [...]

By |2016-09-16T06:19:05+00:00September 16, 2016|Medical Microbiology|Comments Off on Chloramphenicol: Structure and Mechanism of Action | Antibiotics
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Streptomycin: Discovery, Structure and Mechanism | Antibiotics

In this article we will discuss about:- 1. Structure of Streptomycin 2. Antibiotic Spectrum of Streptomycin 3. Mechanism of Action 4. Dependence. Structure of Streptomycin: Streptomycin is characterised chemically as an aminoglycoside antibiotic. It consists of three components linked glycosidically (by ether bonds): (i) Streptidine (inositol with two guanido groups), (ii) Streptose (methyl pentose), and (iii) Streptoscamine (N-methyl-L-glycosamine) as shown [...]

By |2016-09-16T06:19:15+00:00September 16, 2016|Medical Microbiology|Comments Off on Streptomycin: Discovery, Structure and Mechanism | Antibiotics
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Short Notes on Nalidixic Acid | Antibiotics

Nalidixic acid is credited to be the first quinolone synthesized in laboratory in 1962. Its chemical structure is shown in Fig. 45.16. It is a broad spectrum chemotherapeutic agent and is useful against gram-negative bacteria (causing urinary tract infection) and some gram-positive ones. Nalidixic acid is bactericidal and is effective when administered orally. This antibiotic sometimes causes side effects, particularly [...]

By |2016-09-16T06:06:58+00:00September 16, 2016|Medical Microbiology|Comments Off on Short Notes on Nalidixic Acid | Antibiotics
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