In this article we will discuss about:- 1. Discovery of Sulfonamides 2. Structure of Sulfonamides 3. Mode of Action 4. Effectiveness. Discovery of Sulfonamides: The discovery of the sulfonamides or sulfa drugs in 1935 by Professor Gerhard Domagk (Fig. 45.1) and his team was a pioneering achievement in the war against infections, for which Domagk received the 1939 Nobel Prize [...]
In this article we will discuss about:- 1. Discovery of Penicillin 2. Structure and Types of Penicillin 3. Antibiotic Spectrum 4. Mechanism of Action. Discovery of Penicillin: The first penicillin discovered by Alexander Fleming in 1929 as a product of fungus Penicillium notatum was the penicillin G. Also, penicillin G became the first clinically effective antibiotic. Even with the use [...]
In this article we will discuss about:- 1. Structure of Metronidazole 2. Mechanism of Action of Metronidazole 3. Adverse Effects. Structure of Metronidazole: Metronidazole is a nitroimidazole, the class of therapeutic drugs used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Metronidazole (1-(β-hydroxyethyl)-2-methyI-5-nitroimidazole), the chemical structure of which is given in Fig. 45.17 [...]