The following points highlight the three main molecular basis of inherited DNA diseases. The molecular basis are: 1. Genetic Diseases 2. Cleavage of DNA into Fragments 3. DNA Cloning. Molecular Basis # 1. Genetic Diseases: The human genome contains DNA with about 3 billion (109) base pairs that encode 50,000 to 100,000 genes located on 23 pairs of chromosomes. The [...]
The below mentioned article provides a study note on DNA. Nature of DNA: DNA is a very long polymer of purine and pyrimidine mononucleotide monomers bound one to the other by phosphodiester bridges. It exists as a double-stranded molecule in nature. The strands are held together by Vander Waals' forces and the purine and pyrimidine bases of the two strands [...]
Amino acids forming pyruvate are convertible to acetyl-CoA. In addition to this, 5 amino acids form acetyl-CoA directly, without first forming pyruÂvate. Phenylalanine: Phenylalanine (an essential amino acid) is conÂverted to tyrosine by phenylalanine hydroxylase; tetrahydropteridine, NADPH and O, are required. The reaction is not reversible. The catabolism of phenylalanine and tyrosine may be discussed under the following heads: 1. [...]