Factors Decreasing the Bioavailability of Drugs | Toxicology
This article throws light upon the three main factors decreasing the bioavailability of drugs. The factors are: 1. Inactivation 2. First Pass Effect 3. Enterohepatic Recycling. Factor # 1. Inactivation: Inactivation by gastric acid enzymes, bacterial flora. Factor # 2. First Pass Effect: Drug absorbed distal to the oral cavity and proximal to the rectum enters the portal circulation and [...]