This article provides a note on the antimetabolites, explained with the help of suitable diagrams. Folate: MOA By structure folate consists of a pteridine nucleus. PABA and glutamic acid. These folates are taken up into cell actively and converted in presence of DHFR from FH2 into FH4. FH4 acts as a cofactor in the transfer of single carbon fragment via [...]
After reading this article you will learn about various toxicity caused by metals and non metals in animals. 1. Arsenic Poisoning: Inorganic Arsenicals: Arsenic trioxide, arsenic pent-oxide, sodium and potassium arsenate, sodium and potassium arsenite and calcium and lead arsenate are included as inorganic arsenicals. Source: Pasture near smelters, paints, strong solution of lead arsenate- for animal dipping, milk from [...]
After reading this article you will learn about the metabolism of organophosphate esters in animals. Most of the phosphate insecticides are decomposed and excreted rapidly by mammals. Water soluble excretion products are excreted mainly through urine while excretion with the feces is very less. In mammal body toxically active cholinesterase (ChE) inhibitors are formed by oxidation to the 0-analog of [...]