In this article we will discuss about the structure of picornavirus. Each capsid is composed of 60 copies of four structural proteins of which each proto-meter consists of four polypeptides known as VP1, VP2, VP3 and PV4. VP1-VP3 are exposed on the virion surface, while VP4 lies buried in close association with the RNA core (Fig. 17.21). All the VP [...]
Animal viruses differ from stages in mechanism of entering the host cell. This is due to differences in host cell i.e. one is prokaryotic and the other eukaryotic in nature. It is accomplished into the following stages: 1. Attachment: Animal viruses like bacteriophages posses the attachment sites with the help of which it attaches to the receptor sites present on [...]
In this article we will discuss about the replication of picomavirus. The virion RNA is infectious and serves as both the genome and viral messenger RNA. The internal ribosome entry site (IRES) allows direct translation of the polyprotein. The polyprotein is initially processed by the viral protease(s) into various precursor and mature proteins to yield the structural proteins, replicase, VPg, [...]