This article throws light upon the four main terms related to agonist-antagonist interactions. They are: 1. PKX 2. PAX 3. PD’x 4. PDX. Term # 1. PKX: This is an expression for affinity and is defined as negative logarithm of the molar concentration of a drug that elicits an effect representing x% of the maximal response the drug can produce. [...]
Any noxious, undesired and unintended response appearing following prophylactic, diagnostic or therapeutic use of a drug administered at an appropriate dose level and that occurs within a reasonable time frame of administration of the drug is known as an adverse drug reaction. Adverse drug reactions are more commonly observed in human medical practice and such true drug related disorders are [...]
This article throws light upon the five major factors modifying drug effect and dosage. The factors are: 1. Physiological Factors 2. Genetic Factors 3. Pathological Factors 4. Environmental Factors 5. Therapeutic Factors. Factor # 1. Physiological Factors: i. Species: Absolute dose of a drug varies with species as different species are of different sizes, and the amount of drug has [...]