In this article we will discuss about the Metabolism of Pyrimidine Nucleotides:- 1. Biosynthesis of Pyrimidine 2. Catabolism of Pyrimidine 3. Clinical Orientation. Biosynthesis of Pyrimidine: i. The synthesis of pyrimidine ring starts with the formation of carbamoyl phosphate from glutamine, ATP and CO2 being catalyzed by carbamoyl phosphate synthetase, present in the cytosol of the cell. ii. Carbamoyl phosphate [...]
In this article we will discuss about the Metabolism of Purine Nucleotides:- 1. Sources of the Various Atoms of the Purine Base 2. Biosynthesis of Purine Nucleotides [DE NOVO] 3. Salvage Reaction 4. Catabolism 5. Formation of Uric Acid. Contents: Sources of the Various Atoms of the Purine Base Biosynthesis of Purine Nucleotides [DE NOVO] Salvage Reaction of Purine Nucleotides [...]
The below mentioned article provides a short note on Gout. Sodium urate crystals are precipitated out of solution and deposited in soft tissues, particularly in or about joints. These urate deposits are referred to as tophi. Acute inflammatory reactions called acute gouty arthritis is caused by the accumulation of sodium urate crystals in the tissues. The deposition of sodium urate [...]