Nucleosome Model of Chromatin Assembly | Cell Nucleus | Biology

The nucleosome hypothesis proposed by Roger Kornberg in 1974 was a paradigm shift for understanding eukaryotic gene expression. The assembly of DNA into chromatin involves a range of events, beginning with the formation of the basic unit, the nucleosome, and ulti­mately giving rise to a complex organization of specific domains within the nucleus. The first step is the assembly of [...]