The below mentioned article provides a short note on the Conversion of Fibrinogen to Fibrin by Thrombin. Fibrinogen is a soluble plasma glycoprotein whose length is 46 nm. Its molecular weight is 340,000 and it consists of 6 polypeptide chains synthesized in liver. The 6 chains are two Aα chains, two Bβ chains, and two y chains making the structure [...]
The following points highlight the two main heads of catabolism. The heads are: 1. Conversion of Hemoglobin to Bile Pigments 2. Metabolism of Bile Pigments. Catabolism: Head # 1. Conversion of Hemoglobin to Bile Pigments: a. About 8 grams of hemoglobin is broken down each day in the normal adult and this amount contains 27 mg of iron. The protoporphyrin [...]
The following points highlight the three major derivatives of abnormal hemoglobin. The derivatives are: 1. Met-hemoglobin 2. Sulfhemoglobin 3. Carboxyhemoglobin. Derivative # 1. Met-hemoglobin: a. This is an oxidized hemoglobin (ferrous iron is oxidized to ferric iron). Oxygen is in firm combination. b. It is incapable of functioning as an oxygen carrier. Cyanosis usually develops when the concentration of it [...]