In this article we will discuss about the structure and properties of hemoglobins. Structure of Hemoglobins: As indicated by their name, hemoglobins consist of a prosthetic group; the heme (4%) and a protein part: the globin (96%). A. Heme: This is the prosthetic group common to various hemoglobins (while globin varies in different hemoglobins). It contains one molecule of protoporphyrin [...]
The following points highlight the top two types of Porphyrias:- 1. Congenital Porphyrias 2. Acquired Porphyrias Type # 1. Congenital Porphyrias: A. Erythropoietic porphyria. B. Erythropoietic pro-to-porphyria. C. Erythropoietic coproporphyria. D. Hepatic porphyria. (a) Acute intermittent porphyria. (b) Porphyria variegata. (c) Hereditary coproporphyria. (d) Porphyria cutanea tarda. A. Erythropoietic Porphyria: i. Highly increased excretion of uroporphyrin I and, to a [...]
The following points highlight the two main heads of catabolism. The heads are: 1. Conversion of Hemoglobin to Bile Pigments 2. Metabolism of Bile Pigments. Catabolism: Head # 1. Conversion of Hemoglobin to Bile Pigments: a. About 8 grams of hemoglobin is broken down each day in the normal adult and this amount contains 27 mg of iron. The protoporphyrin [...]