In this article we will discuss about the structure and properties of hemoglobins. Structure of Hemoglobins: As indicated by their name, hemoglobins consist of a prosthetic group; the heme (4%) and a protein part: the globin (96%). A. Heme: This is the prosthetic group common to various hemoglobins (while globin varies in different hemoglobins). It contains one molecule of protoporphyrin [...]
The following points highlight the two main heads of catabolism. The heads are: 1. Conversion of Hemoglobin to Bile Pigments 2. Metabolism of Bile Pigments. Catabolism: Head # 1. Conversion of Hemoglobin to Bile Pigments: a. About 8 grams of hemoglobin is broken down each day in the normal adult and this amount contains 27 mg of iron. The protoporphyrin [...]
The following points highlight the three major derivatives of abnormal hemoglobin. The derivatives are: 1. Met-hemoglobin 2. Sulfhemoglobin 3. Carboxyhemoglobin. Derivative # 1. Met-hemoglobin: a. This is an oxidized hemoglobin (ferrous iron is oxidized to ferric iron). Oxygen is in firm combination. b. It is incapable of functioning as an oxygen carrier. Cyanosis usually develops when the concentration of it [...]