Archive | Nucleic Acids

Purine and Pyrimidine Deoxyribonucleosides | Biochemistry

In this article we will discuss about the formation of purine and pyrimidine deoxyribonucleosies. Formation of Purine Deoxyribonucleosides-5'- Triphosphates: The deoxyribonucleotides are simply formed by reduction of the cor­responding ribonucleotides. Thus reduction of carbon 2' of ribose, takes place in E.coli and animal tissues at the ribonucleosides-5'-diphosphates stage, at the cost of a protein of low molecular weight, thioredoxin, comprising [...]

By |2016-12-23T06:26:28+00:00December 23, 2016|Nucleic Acids|Comments Off on Purine and Pyrimidine Deoxyribonucleosides | Biochemistry
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Biosynthesis of DNA | Biochemistry

The biosynthesis of the DNA must consist in a replication or duplication. The study of the DNA structure as proposed by Crick and Watson (see fig. 6-15) gives an idea of the mechanism of this replication. Each nucleotide of the template DNA chain need only be recog­nized by a complementary nucleotide before the latter is incorporated at the end of [...]

By |2016-12-23T06:26:28+00:00December 23, 2016|Nucleic Acids|Comments Off on Biosynthesis of DNA | Biochemistry
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Amino Acids and Formation of Aminoacyl-tRNAs | Biochemistry

In this article we will discuss about the activation of amino acids and formation of aminoacyl-tRNA. The first step of protein biosynthesis comprises two reactions (see fig. 6-43) catalyzed, for a given amino acid, by one and the same enzyme called activation enzyme, or aminoacyl-tRNA synthetase, or aminoacyl-tRNA ligase. In a first step, the L-amino acid is activated by ATP [...]

By |2016-12-23T06:26:28+00:00December 23, 2016|Nucleic Acids|Comments Off on Amino Acids and Formation of Aminoacyl-tRNAs | Biochemistry
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