In this essay we will discuss about the Hardy-Weinberg law of population genetics. The formula (p + q)2 = p2 + 2pq + q2 is expressing the genotypic expectations of progeny in terms of gametic or allelic frequencies of the parental gene pool and is originally formulated by a British mathematician Hardy and a German physician Weinberg (1908) independently. Both [...]
Regarding the genetic structure of the population, the following two hypotheses have been proposed:- 1. Classical Hypothesis 2. Balance Hypothesis. Model # 1. Classical Hypothesis: It was developed by T.H. Morgan (1932) and supported by H.J. Muller and Kaplan (1966). The classical hypothesis proposes that the gene pool of a population consists at each gene locus of a wild-type allele [...]
Application of Hardy-Weinberg law in calculating Gene (Allele) frequencies in a population. The gene frequencies for the autosomal and sex-chromosomal allele can be determined by the help of Hardy-Weinberg law by the following method: A. Calculation of Gene Frequencies of Autosomal Genes: An autosomal gene locus may have codominant alleles, dominant and recessive alleles or multiple alleles. If one desires [...]