Development of chemotherapy may be viewed in three phases:- 1. Pre Ehrlich Period 2. Period of Paul Ehrlich 3. Period highlighted by discovery of sulfonamides and antibiotics. Phase # 1. Pre Ehrlich Period: In this period some compounds were used empirically to treat different diseases. Sometimes adverse effects were also monitored due to empirical use of the compounds. Cinchonabark was [...]
This article provides a note on chloramphenicol. Chloramphenicol is a highly active, broad spectrum antibiotic with excellent pharmacokinetic properties. Source: It is obtained from Actinomyces venezuelae. It is the first antibiotic to be synthesised commercially. Chemistry: It is a derivative of di-chloroacetic acid and contains nitrobenzene moiety. It is a white or grey or yellow fine crystalline powder. It is [...]
Here is a list of nine aminoglycoside antibiotics. 1. Streptomycin: 1. Isolated from streptomyces griseus in 1943. 2. Very soluble in water. 3. Stable compared with penicillin. 4. Pure dry powder remain full potency at room temperature for at least 2 years. 5. Intestinal absorption poor. 6. Used in the treatment of enteritis. 7. Slow absorption from I/M route. 8. [...]