Oxidation of Pyruvate to Acetyl-CoA

In this article we will discuss about the Oxidation of Pyruvate to Acetyl-CoA. 1. Pyruvate oxidatively decarboxylated to acetyl-CoA ("active acetate") before en­tering the citric acid cycle. 2. The reaction is catalysed by the multi-enzyme complex consisting of sev­eral different enzymes. This complex is known as pyruvate dehydrogenase com­plex. 3. Pyruvate is decarboxylated in the pres­ence of thiamine pyrophosphate (TPP) [...]