Oxidation of Pyruvate to Acetyl-CoA
In this article we will discuss about the Oxidation of Pyruvate to Acetyl-CoA. 1. Pyruvate oxidatively decarboxylated to acetyl-CoA ("active acetate") before entering the citric acid cycle. 2. The reaction is catalysed by the multi-enzyme complex consisting of several different enzymes. This complex is known as pyruvate dehydrogenase complex. 3. Pyruvate is decarboxylated in the presence of thiamine pyrophosphate (TPP) [...]